Inflammatory Conditions Nodes under Steady-State As Well As of Plasmacytoid Dendritic Cells to Lymph CCR7 Essentially Contributes to the Homing
نویسندگان
چکیده
منابع مشابه
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
The CC chemokine receptor CCR7 has been identified as a key regulator of homeostatic B and T cell trafficking to secondary lymphoid organs. Data presented here demonstrate that CCR7 is also an essential mediator for entry of both dermal and epidermal dendritic cells (DC) into the lymphatic vessels within the dermis while this receptor is dispensable for the mobilization of Langerhans cells from...
متن کاملPlasmacytoid Dendritic Cells Accumulate and Secrete Interferon Alpha in Lymph Nodes of HIV-1 Patients
Circulating plasmacytoid dendritic cells (pDC) decline during HIV-1 infection, but at the same time they express markedly higher levels of interferon alpha (IFNalpha), which is associated with HIV-1 disease progression. Here we show an accumulation of pDC in lymph nodes (LN) of treatment-naïve HIV-1 patients. This phenomenon was associated with elevated expression of the LN homing marker, CCR7,...
متن کاملPlasmacytoid dendritic cells do not migrate in intestinal or hepatic lymph.
Plasmacytoid dendritic cells (pDCs) recognize pathogen-associated molecules, particularly viral, and represent an important mechanism in innate defense. They may however, also have roles in steady-state tolerogenic responses at mucosal sites. pDCs can be isolated from blood, mucosa, and lymph nodes (LNs). Although pDCs can express peripherally derived Ags in LNs and at mucosal sites, it is not ...
متن کاملInflammatory dendritic cells in mouse and human 1
2 Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. 3 Several murine DC subsets have been identified that differ in their phenotype and functional 4 properties. In the steady state, DC precursors originating from the bone marrow give rise to 5 lymphoid organ-resident DCs and to migratory tissue DCs. During inflammation, an 6 additional DC subset has ...
متن کاملPlasmacytoid dendritic cells in angiolymphoid hyperplasia with eosinophilia
Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is characterized by irregularly-shaped blood vessels with an inflammatory infiltrate. While absent from normal skin, plasmacytoid dendritic cells (pDCs) infiltrate the skin upon injury and during several infectious, inflammatory, and neoplastic entities. In addition to providing anti-viral resistance, pDCs link the innate and adapti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011